MAJOR DISCOVERIES RELATED TO AUTISM REVEALED BY 3D BRAIN TISSUE
Major discoveries were made possible in USA, with the work of a team coordinated by a Romanian professor. The great discovery is just the beginning of a new way of observing and helping future generations. This awakening was possible due to the use of Inducted Pluripotent Stem Cells.
Biomedical research is one of the most challenging fields because the brain is the most complex part of the human body.
Since not ethically correct, scientist cannot access the cells of alive adult’s brain so mainly their work is similar to that of a detective investigation tracing back to fetal brain development and gathering clues after autism occurs.
Stanford University is giving access to new research based on induced pluripotent stem cells (IPSC’s). Dr. Sergiu Pasca and his team recreated the types of nerves cell circuits in the fetal cerebral cortex and observed irregularities of brain circuiting.
What is amazing, is the fact that the formation of the cortex’s neuron circuits is complete after the connection with the migrating neurons that can turn off and on a nerve signal.
By deriving the two different brain sphere areas, one in the cortical cortex and one containing the inhibitory neurons, Pasca’s team observed that they fused spontaneously.
The patient’s skin cells suffering from Timothy Syndrome ( a rare form of autism) used in the experiments helped observe that the mutated gene is responsible for the production of a protein that helps shuttle calciumin and aut of neurons. The result is a slow neuron migration.
Pasca and his team are excited to discover more about the development of the fetal brain and individualise each type of brain disfunction.
Here is the link to the great discoveries of Dr. Sergiu Pasca and his team. https://blog.cirm.ca.gov/2017/05/01/seeing-the-entire-movie-not-just-snapshots-of-stem-cell-derived-brain-cells-reveals-autism-insights/